化学学报 ›› 2012, Vol. 70 ›› Issue (03): 357-362.DOI: 10.6023/A1107101 上一篇    下一篇

研究论文

新型含2,5-二-(3,5-二甲基吡唑-4-巯基)-1,3,4-噻二唑-M (M=Co2+, Cd2+, Mn2+)配合物的合成、晶体结构及其抑菌活性研究

张奇龙a, 袁泽利b, 张云黔c, 朱必学c   

  1. a 贵阳医学院化学教研室 贵阳 550004;
    b 遵义医学院药学系 遵义 563003;
    c 贵州省大环化学及超分子化学重点实验室 贵阳 550025
  • 收稿日期:2011-07-10 修回日期:2011-09-05 出版日期:2012-02-14 发布日期:2011-10-25
  • 通讯作者: 张云黔 E-mail:gzuqlzhang@126.com
  • 基金资助:

    国家自然科学基金(No. 21061003)、贵州省自然科学基金(No. [2011]2287)资助项目.

Synthesis, Crystal Structure and Bacteriostatic Activity of M (M=Co2+, Cd2+, Mn2+) Complex with 2,5-Bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole

Zhang Qilonga, Yuan Zelib, Zhang Yunqianc, Zhu Bixuec   

  1. a Department of Chemistry, Guiyang Medical College, Guiyang 550004;
    b Department of Pharmacy, Zhunyi Medical College, Zhunyi 563003;
    c Key Laboratory of Macrocycle and Supramolecular Chemistry, Guiyang 550025
  • Received:2011-07-10 Revised:2011-09-05 Online:2012-02-14 Published:2011-10-25
  • Supported by:

    This work was supported by the National Natural Science Foundation of China (No. 21061003) and the Natural Science Foundation of Guizhou Province (No. [2011]2287).

将配体L [2,5-二-(3,5-二甲基吡唑-4-巯基)-1,3,4-噻二唑]与Co(NO3)2·6H2O, Cd(NO3)2·4H2O 和MnCl2·4H2O 进行配位反应, 得到三个配合物[Co(L)2(H2O)4](NO3)2 · 4(CH3CH2OH) (1), [Cd(L)2(H2O)4](NO3)2 · 4(CH3CH2OH) (2),[Mn(L)2(Cl)2(CH3OH)2]·2(CH3OH) (3), 并用元素分析, FT-IR 和X 射线单晶衍射进行了表征. 分析结果表明, 配体L 呈“U”形, 配合物13 呈“S”形. 配合物中Co(Ⅱ), Cd(Ⅱ), Mn(Ⅱ)的配位环境均为扭曲八面体, 每个金属离子同时和两个配体进行配位. 配体和配合物体外抑菌活性研究结果表明, 配体及其配合物都有一定的抑菌活性.

关键词: 配合物, 晶体结构, 抑菌活性

Three complexes [Co(L)2(H2O)4](NO3)2·4(CH3CH2OH)(1), [Cd(L)2(H2O)4](NO3)2·4(CH3CH2- OH) (2) and [Mn(L)2(Cl)2(CH3OH)2]·2(CH3OH) (3) were synthesized from the reaction of 2,5-bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole with Co(NO3)2·6H2O, Cd(NO3)2·4H2O and MnCl2·4H2O, and characterized by elemental analysis, FT-IR and single crystal X-ray diffraction. The results of structural analysis indicate that the ligand (L) was adopted “U” configuration, and each complex shows a “S” conformation. In three complexes, the coordination environment of each metal center show a distorted octahedral geometry, and each metal ion was coordinated with two ligands. The bacteriostatic activity results indicated that both of the ligand and complexes possess some bacteriostatic effect.

Key words: complex, crystal structure, bacteriostatic activity