### “受阻路易斯酸碱对”催化的不对称氢化反应

1. 中国科学院化学研究所 中国科学院分子识别与功能重点实验室 北京 100190
• 投稿日期:2014-04-30 发布日期:2014-05-14
• 通讯作者: 杜海峰 E-mail:haifengdu@iccas.ac.cn
• 基金资助:
项目受国家自然科学基金优秀青年基金（No.21222207）资助.

### Frustrated Lewis Pair Catalyzed Asymmetric Hydrogenation

Liu Yongbing, Du Haifeng

1. CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
• Received:2014-04-30 Published:2014-05-14
• Supported by:
Project supported by the National Natural Science Foundation of China (No. 21222207).

Catalytic asymmetric hydrogenation of unsaturated substrates is one of the most important transformations in organic chemistry, which provides a significant approach to produce optically active compounds both in academia and chemical industry due to its atom-economy and high efficiency. Since the original work of Knowles and Sabacky in 1960s, transition-metal-catalyzed asymmetric hydrogenation has been well developed with great achievements. However, metal-free asymmetric hydrogenation utilizing molecular hydrogen is extremely challenging, and has long been an unsolved problem. Frustrated Lewis pairs (FLPs) with a combination of sterically encumbered Lewis acids and Lewis bases preclude the formation of classical Lewis acid-base adducts via dative bonds due to the steric effects, and they therefore possess novel and interesting properties and reactivities. Since frustrated Lewis pairs was first disclosed to enable heterolytic cleavage of H2 reversibly by Stephan and co-workers in 2006, its applications on activating various of small molecules such as H2, CO2, NO and catalytic hydrogenation of unsaturated compounds were reported. Asymmetric hydrogenation under H2 by metal-free catalysts has been realized and has witnessed important progress. In this perspective, the achievements on frustrated Lewis pair catalyzed asymmetric hydrogenation are discussed from two aspects: (1) asymmetric hydrogenation induced by chiral substrates; (2) asymmetric hydrogenation catalyzed by chiral frustrated Lewis pairs.