化学学报 ›› 2017, Vol. 75 ›› Issue (1): 70-73.DOI: 10.6023/A16080407 上一篇    下一篇

所属专题: 有机光化学

研究通讯

可见光催化有氧脱氢合成2,3-二氢-4-吡啶酮与4-喹诺酮

邵天举, 江智勇   

  1. 河南大学 河南省天然药物与免疫工程重点实验室 开封 475004
  • 收稿日期:2016-08-13 修回日期:2016-09-26 出版日期:2017-01-15 发布日期:2016-09-27
  • 通讯作者: 江智勇,E-mail:chmjzy@henu.edu.cn E-mail:chmjzy@henu.edu.cn

Visible Light Mediated Photocatalytic Aerobic Dehydrogenation: A General and Direct Approach to Access 2,3-Dihydro-4-Pyridones and 4-Quinolones

Shao Tianju, Jiang Zhiyong   

  1. Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004
  • Received:2016-08-13 Revised:2016-09-26 Online:2017-01-15 Published:2016-09-27
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21072044, 21672052) and the Science and Technology Department of Henan Province (Nos. 14IRTSTHN006, 152300410057).

报道了一种可见光促进4-哌啶酮及2,3-二氢-4-喹诺酮的有氧脱氢化方法.研究中通过使用一种二腈基哌嗪化合物(dicyanopyrazine-derived chromophore,DPZ)为光催化剂,能够以令人满意的分离产率(最高75%)分别合成出2,3-二氢-4-吡啶酮与4-喹诺酮.本反应为这两类重要含氮杂环化合物提供了一种直接的、可持续的以及高原子经济性的合成途径.

关键词: 可见光催化, DPZ, 脱氢化, 吡啶酮, 喹诺酮

A visible-light-induced photocatalytic aerobic dehydrogenation of 4-piperidones and 2,3-dihydro-4-quinolones has been developed. By utilizing dicyanopyrazine-derived chromophore (DPZ) as the photocatalyst, the dehydrogenation could provide 2,3-dihydro-4-pyridones and 4-quinolones with satisfactory results (up to 75% yield). The current methodology presents a direct, sustainable and highly atom-economic approach to access these valuable N-containing heterocycles.

Key words: visible light photocatalysis, DPZ, dehydrogenation, pyridone, quinolone