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基于壳聚糖物理网络的高强韧双网络水凝胶的构建、调控与应用

杨艳宇a,b, 王星b, 吴德成b,c   

  1. a 郑州大学材料科学与工程学院 郑州 450001;
    b 中国科学院化学研究所 北京 100190;
    c 南方科技大学生物医学工程系 深圳 518055
  • 发布日期:2020-09-16
  • 通讯作者: 王星, 吴德成 E-mail:wangxing@iccas.ac.cn;dcwu@iccas.ac.cn
  • 基金资助:
    项目受国家自然科学基金(Nos.51803188,51973226,21725403)资助

Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications

Yang Yanyua,b, Wang Xingb, Wu Dechengb,c   

  1. a College of Materials Science and Engineering, Zhengzhou University, Zhengzhou,450001;
    b Beijing National Laboratory for Molecular Sciences, Institute of Chemistry,Chinese Academy of Sciences, Beijing 100190;
    c Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055
  • Published:2020-09-16
  • Supported by:
    Project supported by the National Science Foundation of China (51803188, 51973226 and 21725403).

双网络水凝胶由两个具有相反物理性质的交联网络构成,硬而脆的第一网络在变形过程中断裂耗散能量,从而增韧凝胶。当第一网络为具有重建能力的物理网络时,双网络水凝胶表现出优异的抗软化和机械稳定性。目前双网络水凝胶第一物理网络类型单一、结构和力学调控繁琐,因而其开发和应用受到限制。针对上述问题,我们发展了硬而脆的壳聚糖物理网络构建的新策略,壳聚糖的网络类型、结构和物理性质均能简便调控,然后将其作为第一网络成功地制备了多种高强韧且结构性能可灵活调控的双网络水凝胶,在抗冻敷料、生物医用、柔性电子和可穿戴设备等领域具有重要的应用价值。构建壳聚糖基双网络水凝胶的策略操作简单、普适通用,能够有力促进高强韧水凝胶的开发、功能化及应用。

关键词: 壳聚糖物理网络, 高强韧水凝胶, 性能调控, 耐冻性, 柔性可穿戴设备

Double-network (DN) hydrogels are composed of two asymmetric networks with contrasting properties, wherein the rigid and brittle network serving as sacrificial bonds effectively dissipates energy to enhance the mechanical performance. The first reconstructable physical network endows the DN hydrogels with outstanding anti-soften and mechanical stability. However, the monotonous type of physical networks and the difficulty in tailoring structure and mechanics greatly limit the development and application of DN hydrogels. Focusing on these problems, we have fabricated the rigid and brittle chitosan physical network with adjustable network type, structure and property and further constructed various chitosan-based DN hydrogels with high mechanical performance and tunable mechanics. The hydrogels were great potential materials for anti-freezing dresses, biomedical materials, flexible electronics and wearable devices. The universal strategy of constructing chitosan-based DN hydrogels was beneficial for developing various functional and high-mechanical hydrogels and broadening their applications.

Key words: chitosan physical network, strong and tough hydrogel, structural and mechanical regulation, freezing tolerance, flexible wearable device