化学学报 ›› 1994, Vol. 52 ›› Issue (8): 813-816. 上一篇    下一篇

研究论文

大环二萜圆盘肉芝内酯的分子构型研究

苏镜娱;钟永利;娄瑰霞;李小清;曾陇梅;黄幼青;胡盛志   

  1. 中山大学化学系;厦门大学化学系
  • 出版日期:1994-08-15 发布日期:1994-08-15

Studies on the stereochemistry of (-)-sartrochine

SU JINGYU;ZHONG YONGLI;LOU GUIXIA;LI XIAOQING;ZENG LONGMEI;HUANG YOUQING;HU SHENGZHI   

  • Online:1994-08-15 Published:1994-08-15

从南海圆盘肉芝软珊瑚(Sarcophyton trochliphroum)中分离得一个新的大环二萜内酯化合物-圆盘肉芝内酯(Sartrochine), 生物测定表明其具有抗肿瘤及抑菌作用。通过波谱分析, X射线单晶衍射及CD谱确定其绝对构型。

关键词: 晶体结构, X射线衍射分析, 圆振二向色性, 生物测定, 软珊瑚, 抗癌活性, 圆盘肉芝内酯

A new macrocyclic diterpenoid lactone, (-)-sartrochine (I), was isolated from the soft coral Sarcophyton trocheliophorum, which showed cytotoxic activity against S180 cells and antibiotic effect on Streptococcus. The mol. structure and the relative stereochem. were determine by spectroscopic data and x-ray diffraction anal. The absolute configuration was assigned by CD method.

Key words: CRYSTAL STRUCTURE, X-RAY DIFFRACTION ANALYSIS, CIRCULAR DICHROISM, BIOLOGICAL TESTS, SOFT CORAL, ANTINEOPLASTIC ACTIVITY

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