化学学报 ›› 1994, Vol. 52 ›› Issue (8): 823-830. 上一篇    

研究论文

香芹酮的双重Michael反应和在天然产物手性合成中的应用

赵玉芬;赵荣宝;吴毓林   

  1. 中国科学院上海有机化学研究所;中国科学院生命有机化学国家重点实验室
  • 出版日期:1994-08-15 发布日期:1994-08-15

Double michael reaction of carvone and its utilization in chiral synthesis of natural products

ZHAO YUFEN;ZHAO RONGBAO;WU YULIN   

  • Online:1994-08-15 Published:1994-08-15

香芹酮与α, β-不饱和酯顺利进行双重Michael加成反应, 所得光学活性的[2.2.2]桥环化合物为一些天然产物的手性合成提供了十分有用的中间体。本文报道了这两方面的研究进展。

关键词: 酯, 香芹酮, 桥环化合物, 迈克尔加成反应, 天然产物, 手性合成

The double Michael reaction of carvone and Me methacrylate was described in detail. Its product, an optically active bicyclo[2.2.2]octane derivative I, is a useful intermediate for the chiral synthesis of natural products. In this respect an elemene derivative and an intermediate for the synthesis of (+)-curdione were synthesized.

Key words: ESTERS, CARVONE, BRIDGE COMPOUNDS, MICHAEL ADDITION REACTION, NATURAL PRODUCTS

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