化学学报 ›› 1995, Vol. 53 ›› Issue (6): 620-624. 上一篇    

研究论文

从尿核苷合成异胞苷衍生物的简便有效方法

曾福金   

  1. 中国科学院上海有机化学研究所
  • 出版日期:1995-06-15 发布日期:1995-06-15

A simple and efficient method for synthesis of isocytidine derivatives from uridine

ZENG FUJIN   

  • Online:1995-06-15 Published:1995-06-15

本文报道从5'-O-磺酰基-2',3'-O-异亚丙基尿核苷通过一步法合成N-烷基2',3'-O-异亚丙基异胞苷和从5'-O-对甲苯磺酰基尿核苷合成5'-脱氧-5'-异丙氨基尿核苷。并对以上产物形成的机制作了探讨。

关键词: 合成, 尿核苷, 异胞苷衍生物

Isocytidine derivatives (4~8) has been synthesized in reasonable yield in one step by reaction of uridine derivatives 1,2 and 3 with alkylamine in the presence of triethylamine at room temperature, while the reaction of 5'-O-(p-tolylsulfonyl)-uridine with isopropylamine gives 5'-deoxy-5'-isopropylaminouridine is same conditions. A plausible mechanism of the reaction is proposed.

Key words: SYNTHESIS

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