化学学报 ›› 1996, Vol. 54 ›› Issue (12): 1200-1208. 上一篇    下一篇

研究论文

一种新的四糖柴胡皂苷结构的NMR研究

马立斌;金怡珠;涂光忠;罗何生;赵玉英;胡长风;张如意;来鲁华;徐筱杰;唐有祺   

  1. 北京微量化学研究所;北京医科大学药学院植化室;北京大学化学系
  • 出版日期:1996-12-15 发布日期:1996-12-15

The structure study of a new saikosaponin

MA LIBIN;JIN YIZHU;TU GUANGZHONG;LUO HESHENG;ZHAO YUYING;HU CHANGFENG;ZHANG RUYI;LAI LUHUA;XU XIAOJIE;TANG YOUQI   

  • Online:1996-12-15 Published:1996-12-15

本文报道从小叶黑柴胡(Bupleurum Smithii Wolff Var. Parvitolium Shanet Y. Li)分离出的一种新皂苷, 应用COSY, CH-COSY, TOCSY, HMQC-COSY, HMBC等NMR方法对其结构进行了研究, 确定该化合物为3β, 16β, 23, 28-四羟基齐墩果烷-11,13(18)-二烯-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基-(1→6)-[β-D-吡喃葡萄糖基-(1→2)]-β-D-吡喃葡萄糖苷(1), 命名为柴胡皂苷O(Saikosaponin O)。

关键词: 齐墩果烷, 柴胡皂苷, NMR, HMQC, HMBC, COSY, TOCSY, 吡喃葡萄糖苷 P

Saikosaponin O was isolated from Bupleutum smithii Wolff var. parvifolium Shan et Y. Li. Its structure was determinated by NMR methods. From TOCSY and DQF-COSY spectra, the residues of monosaccharides and all their assignments were acquired. The anomeric configurations were obtained by ^3J~H~1~H~2. The HMQC-COSY spectrum was used successfully for ^1^3C assignment since it was difficult to do it only by CH-COSY spectrum. All the glucosidic linkages were obtained from HMBC spectrum based on the ^1H and ^1^3C assignments, NOESY spectrum also gave the concordant result about the configurations and the linkage positions.

Key words: OLEANANE, NMR, HMQC, HMBC

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