化学学报 ›› 2005, Vol. 63 ›› Issue (6): 450-454. 上一篇    下一篇

研究论文

季铵盐表面活性剂与卵磷脂囊泡相互作用的研究

张春艳,徐晓明,吴章锋,韩国彬*   

  1. (厦门大学化学系 固体表面物理化学国家重点实验室 厦门 361005)
  • 收稿日期:2004-07-14 修回日期:2004-11-26 出版日期:2005-03-28 发布日期:2010-12-10
  • 通讯作者: 韩国彬

Investigation on the Interaction between Quaternary Ammonium Surfactants and Lecithin Vesicles

ZHANG Chun-Yan, XU Xiao-Ming, WU Zhang-Feng, HAN Guo-Bin*   

  1. (Department of Chemistry, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005)
  • Received:2004-07-14 Revised:2004-11-26 Online:2005-03-28 Published:2010-12-10
  • Contact: HAN Guo-Bin

采用动态光散射、ζ电势等方法研究了季铵盐二聚表面活性剂(C12-8-C12•2Br)和十二烷基三甲基溴化铵(DTAB)在卵磷脂囊泡中的增溶作用. C12-8-C12•2Br使囊泡粒径增大, 促进脂双层向胶团的转变, 过程明显分为三个阶段; 而DTAB与囊泡的作用则相对缓和, 72 h内未见明显变化. 此外, 用亲水头基总体积的大小, 讨论了这两种表面活性剂在脂质体中的吸附行为, 并对实验现象加以解释说明.

关键词: 季铵盐表面活性剂, 脂质体, 增溶作用, 动态光散射, ζ电势

The solubilization process of quaternary ammonium surfactants within lecithin vesicles has been studied by means of optical density monitoring, dynamic light scattering (DLS) and ζ-potential. To C12-8-C12•2Br-liposome system, the vesicle-to-micelle structure transition occurred within 6 h, and could be described by a simple three-stage model. While the DTAB-liposome system remained vesicle state even after 48 h. The size of total volume of hydrophilic head group (Vhead) as the main influencing factor was investigated.

Key words: quaternary ammonium surfactant, liposome, solubilization process, dynamic light scattering, ζ-potential