化学学报 ›› 2005, Vol. 63 ›› Issue (6): 525-532. 上一篇    下一篇

研究论文

含均三唑环的新型联苯四唑衍生物的合成及抗菌活性

晁淑军1,惠新平1,李硕1,许鹏飞*,1,张自义1,王勤2,王燕玲2   

  1. (1兰州大学 功能有机分子化学国家重点实验室 化学化工学院 兰州 730000)
    (2兰州大学生命科学学院 兰州 730000)
  • 收稿日期:2004-08-04 修回日期:2004-11-28 出版日期:2005-03-28 发布日期:2010-12-10
  • 通讯作者: 许鹏飞

Synthesis and Antibacterial Activities of New Biphenyltetrazole Derivatives Bearing 1,2,4-Triazole

CHAO Shu-Jun1, HUI Xin-Ping1, LI Shuo1, XU Peng-Fei*,1, ZHANG Zi-Yi1, WANG Qin2, WANG Yan-Ling2   

  1. (1 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000)
    (2 College of Life Science, Lanzhou University, Lanzhou 730000)
  • Received:2004-08-04 Revised:2004-11-28 Online:2005-03-28 Published:2010-12-10
  • Contact: XU Peng-Fei

通过4-芳基-5-(4-吡啶基)-1,2,4-三唑-3-硫醇(1)和2-三苯基甲基-5-(4′-溴甲基联苯-2-基)-四唑(5)反应, 制得一系列新的S-烷基化产物(6), S-烷基化产物在酸性条件下脱保护, 得到了14个未见文献报道的含1,2,4-三唑类联苯四唑(7a7n)衍生物. 结构经元素分析, IR, NMR及FAB-MS确认. 对大肠杆菌、链球菌、枯草杆菌、金黄色葡萄球菌初步抑菌试验证明, 多数化合物表现了较好的抑菌活性.

关键词: 1,2,4-三唑, 2-(2H-四唑-5-基)联苯, 抑菌活性

S-Alkylation products were synthesized by the reaction of 4-aryl-5-(4-pridyl)-1,2,4-triazole-3- thiol (1) with 2-trityl-5-(4′-bromomethylbiphen-2-yl)tetrazole (5). An attempt to remove the trityl group of S-alkylation products 6 under acidic conditions gave fourteen new triazole ring containing biphenyl tetrazoles 7a7n in good yields. The structures of these compounds synthesized were confirmed by elemental analyses, IR, NMR and FAB-MS. Primary antibacterial test against E. coli, Streptococcus, B. subtilis and S. aureus showed that most of them had good antibacterial activities.

Key words: 1,2,4-triazole, 2-(2H-tetrazol-5-yl)biphenyl, antibacterial activity