化学学报 ›› 2012, Vol. 0 ›› Issue (04): 519-524.DOI: 10.6023/A1109102 上一篇    

研究简报

铋(III)苯乙酸-1,10-邻菲罗啉三元配合物[Bi2(PPA)6·(Phen)2]的合成、 晶体结构及抑菌活性

杨树平a, 韩立军b, 潘燕c, 吴争鸣a, 何欣然a, 陈丽娟a   

  1. a 淮海工学院化学工程学院 连云港 222005;
    b 淮海工学院数理学院 连云港 222005222005;
    c 北京大学医学部基础医学院药理系及国家天然仿生药物重点实验室 北京 100191
  • 收稿日期:2011-09-10 修回日期:2011-11-18 出版日期:2012-02-28 发布日期:2011-12-19
  • 通讯作者: 杨树平
  • 基金资助:

    国家自然科学基金(No. 30901815)和淮海工学院自然科学基金(No. Z2009019)资助项目.

Synthesis, Crystal Structure and Antibacterial Activity of A Bismuth(III) Complex [Bi2(PPA)6?(Phen)2] with Phenylacetic Acid and 1,10-Phenanthroline

Yang Shupinga, Han Lijunb, Pan Yanc, Wu Zhenminga, He Xinrana, Chen Lijuana   

  1. a School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005;
    b School of Mathematics and Science, Huaihai Institute of Technology, Lianyungang 222005;
    c Department of Pharmacology, School of Basic Medical Sciences and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191
  • Received:2011-09-10 Revised:2011-11-18 Online:2012-02-28 Published:2011-12-19
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 30901815) and Natural Science Foundation of Huaihai Institute of Technology, China (No. Z2009019).

合成了铋(III)苯乙酸-1,10-邻菲罗啉[Bi2(PPA)6·(Phen)2] (HPPA=苯乙酸(C8H7O2), Phen = l,10-邻菲罗啉 (C12H8N2))三元配合物, 并通过元素分析和红外(IR)光谱对其进行了表征, 用单晶X-射线衍射测定了配合物的晶体结构. 配合物属于三斜晶系, P-1 空间群, a=0.9100(6) nm, b=1.2617(8) nm, c=1.3324(9) nm, α=89.757(8)°, β= 87.277(8)°, γ=81.155(8)°, V=1.5099(17) nm3, Dc=1.748 g·cm-3, μ=5.890 mm-1, Z=1, F(000)=780, 残差因子R1= 0.0484, wR2=0.1090 [I>2σ(I)], S=1.002. 标题化合物为双核铋(III)配合物, 金属中心Bi(III)原子与三个苯乙酸根(PPA) 中的6 个氧原子、一个1,10-邻菲罗啉分子中的两个氮原子和一个桥连氧原子进行配位, 形成九配位的扭曲三帽三方柱配位十四面体, 围绕铋原子的价键总数VBi(1)=2.897, 两个Bi(III)原子通过两个桥连氧原子连结成中心对称的分子, Bi…Bi 间距离为0.4469(2) nm. 初步抑菌试验结果显示, 配合物对大肠杆菌(E. Coli)、金黄色葡萄球菌(S. Aureus)、枯草芽孢杆菌(B. Subtilis)表现出相似且良好的抑菌效果.

关键词: 铋(III)配合物, 晶体结构, 抗菌活性, 苯乙酸, 邻菲罗啉

A bismuth(III) complex [Bi2(PPA)6·(Phen)2] (HPPA = phenylacetic acid; Phen = 1,10-phenanthroline) was synthesized and characterized by elemental analysis and infrared (IR) spectroscopy, its crystal structure was determined by single crystal X-ray diffraction. The crystal of bismuth(III) complex belongs to triclinic system with space group P-1, a=0.9100(6) nm, b=1.2617(8) nm, c= 1.3324(9) nm, α=89.757(8)°, β=87.277(8)°, γ=81.155(8)°, V=1.5099(17) nm3, Dc=1.748 g·cm-3, μ=5.890 mm-1, Z=1, F(000)=780, residual factors R1=0.0484, wR2=0.1090 [I>2σ(I)], S=1.002. The comcomplex is a binuclear bismuth(III) compound, and every bismuth(III) atom is nine-coordinated by six O atoms from three ligands (PPA) and two N atoms from one ligand (Phen) and one bridged O atom, and the coordination polyhedron around the bismuth(III) atom can be best described as a distorted tricapped trigonal-prismatic tetrakaidecahedron geometry, the valence sum of around Bi atom VBi(1)=2.897. The distance of Bi…Bi is 0.4469(2) nm. The complex has a good effect against E. Coli, S. Aureus and B. Subtilis.

Key words: bismuth(III) complex, crystal structure, antibacterial activity, phenylacetic acid, 1,10-phenanthroline