化学学报 ›› 2012, Vol. 70 ›› Issue (12): 1385-1393.DOI: 10.6023/A1201061 上一篇    下一篇

研究论文

二酰胺大环化合物与吡啶N-氧化物的络合作用研究

杨登科a, 曾志坚b, 陈木娟a, 潘绍武a, 杨宇a, 李媚a, 雷春燕a, 蒋腊生a   

  1. a 华南师范大学化学与环境学院 广州 510006;
    b 华南师范大学实验中心 广州 510006
  • 收稿日期:2012-01-06 修回日期:2012-03-20 出版日期:2012-06-28 发布日期:2012-03-29
  • 通讯作者: 蒋腊生 E-mail:jiang6128@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(No. 21072066)资助项目.

Studies on the Complexation of di-Amide Based Macrocycles with Pyridine N-oxides

Yang Dengkea, Zeng Zhijianb, Chen Mujuana, Pan Shaowua, Yang Yua, Li Meia, Lei Chunyana, Jiang Lashenga   

  1. a School of Chemistry and Environment, South China Normal University, Guangzhou 510006;
    b Research Resources Centre, South China Normal University, Guangzhou 510006
  • Received:2012-01-06 Revised:2012-03-20 Online:2012-06-28 Published:2012-03-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21072066).

通过吡啶二酰胺大环与碘甲烷反应合成了一种阳离子型大环主体化合物, 并用NMR, ESI-MS 进行了结构表征.采用ESI-MS 和1H NMR 方法研究了合成的主体化合物与吡啶N-氧化物客体的相互作用, 通过核磁滴定测定了主客体络合物的络合常数. 实验结果表明阳离子型大环化合物2 不仅能与吡啶N-氧化物形成1∶1 准轮烷型络合物, 而且其络合常数Ka 比相应的中性大环化合物1 有显著提高.

关键词: 大环化合物, 主客体化学, 络合作用, 准轮烷

A new cationic host molecule was synthesized by reaction of the di-amide based macrocycle with methyl iodide and the structure was confirmed by NMR, ESI-MS spectra. The complexation behavior of the di-amide based macrocycles with pyridine N-oxide guests was investigated by means of ESI-MS and 1H NMR. The results showed that the cationic host can not only bind the pyridine N-oxide hosts to form 1∶ 1 pseudorotaxane-like complexes but also have much stronger binding ability than the corresponding neutral hosts.

Key words: macrocycles, host-guest chemistry, complexation, pseudorotaxane