a State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University and College of Chemistry and Chemical Engineering, Changsha 410082;
b Department of Chemistry and Chemical Engineering, Huaihua University, Huaihua 418000
Abstract：The recent development of new gold(I) catalytic methods has opened the door to the total synthesis of natural products and bioactive complex molecules. We describe a convenient, straightforward, efficient and environmentally benign protocol to synthesize the 5-(3-indolyl)oxazole. The new synthetic route was finished in five steps including iodization, N-Boc protection, Sonogashira cross-coupling, gold catalyzed reaction, deprotection using indole as the starting material. The key step was generation of α-oxo carbene via gold-catalyzed intermolecular oxidation of alkynes (2).