化学学报 ›› 1958, Vol. 24 ›› Issue (6): 431-435. 上一篇    下一篇

论文

1, 6-消除反应的初步研究

黄文洪1, 黄鸣龙2   

  1. 1. 广州中山大学化学系;
    2. 中国科学院有机化学研究所
  • 收稿日期:1958-08-05 出版日期:1958-12-15 发布日期:2013-06-03

A PRELIMINARY STUDY ON 1, 6-ELIMINATION

HUANG WEN-HUNG1, HUANG-MINLON2   

  1. Institute of Organic Chemistry, Academia Sinica
  • Received:1958-08-05 Online:1958-12-15 Published:2013-06-03

“1, 6-消除反应”首先由作者之一等提出, 这类反应是指δ-取代的αβ-不饱和羰基化合物在酸或硷的催化作用下脱去取代基, 并形成αβ, γδ-二烯酮(或醛)的反应.由于取代基所在的碳原子与羰基氧原子的相对位置是“1”与“6”, 故称为1, 6-消除反应.

A semiquantitative comparison.on the relative rates of 1, 6-elimination of several δ-substituted.α, β-unsaturated steroidal keton.es was carried out spectropho-tometrically.The preliminary results indicated that the rate of elimination is faster in dilute alkaline medium than is in acidic medium, and the axial δ-substituent is more readily elixninated than the corresponding equatorial ones.