Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (04): 505-511.DOI: 10.6023/A1108302 Previous Articles     Next Articles

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ARGET ATRP 与ROP 结合制备pH 响应两亲性聚合物分子刷及其自组装研究

杨友强, 孙清清, 张灿阳, 郭新东, 章莉娟, 文秀芳   

  1. 华南理工大学化学与化工学院 广州 510640
  • 投稿日期:2011-08-30 修回日期:2011-10-30 发布日期:2011-11-09
  • 通讯作者: 章莉娟
  • 基金资助:

    国家自然科学基金(No. 21176090)、广东省自然科学基金团队项目(No. S2011030001366)、广东省自然科学基金(No. 9251064101000009)、广州市应用基础研究计划(No. 2009J1-C511-2)和中央高校基本科研业务费专项资金(No. 2011ZM0041)资助项目.

Synthesis of pH-Sensitive Amphiphilic Copolymer Brush by the Combination of ARGET ATRP with ROP and Its Self-Assembly Behavior

Yang Youqiang, Sun Qingqing, Zhang Canyang, Guo Xindong, Zhang Lijuan, Wen Xiufang   

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
  • Received:2011-08-30 Revised:2011-10-30 Published:2011-11-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21176090), Team Project of Natural Science Foundation of Guangdong Province (No. S2011030001366), Guangdong Province Science Foundation (No. 9251064101000009), Guangzhou Municipal Bureau of Science and Technology (No. 2009J1-C511-2) and the Fundamental Research Funds for the Central Universities (No. 2011ZM0041).

A random hydrophobic/pH-sensitive copolymer brush poly(polylactide methacrylate-comethacrylic acid)-b-poly(poly(ethylene glycol) methyl ether methacrylate) [P(PLAMA-co-MAA)-b-PPEGMA] was synthesized by the combination of activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) with ring opening polymerization (ROP). The chemical structure, molecular weight and polydispersity index were characterized by nuclear magnetic resonance hydrogen spectrum (1H NMR) and gel permeation chromatography (GPC). The reaction conditions of polymerization were optimized and polymer products with controllable molecular weight and narrow distribution were obtained. The self-assembly behavior (micelle size, morphology and pH-sensitive properties) of the polymer brush was investigated by dynamic light scattering (DLS) and scanning electron microscopy (SEM). The P(PLAMA-co-MAA)-b-PPEGMA self-assembled micelles were sphere in morphology and with an uniform particle size. As the solution pH decreased from 7 to 3, the deionization of carboxyl groups of PMAA contributed to the shrinking of micelle structure, which made the micelle size decreased from 200~300 nm to about 150 nm. When the solution pH decreased to below 2, the surface charge of micelle became very small which resulting in the aggregation of micelles and the increase of micelle size.

Key words: pH-sensitive, polymer brush, self-assembled micelle, ARGET ATRP, ROP