Acta Chimica Sinica ›› 2014, Vol. 72 ›› Issue (7): 798-808.DOI: 10.6023/A14040325 Previous Articles     Next Articles

Special Issue: 不对称催化与合成



季益刚a,c, 吴磊a, 范青华b   

  1. a 南京农业大学 理学院化学系 南京 210095;
    b 中国科学院化学研究所 分子识别与功能院重点实验室 北京 100190;
    c 江苏第二师范学院 生命科学与化学化工学院 南京 210013
  • 投稿日期:2014-04-25 发布日期:2014-05-07
  • 通讯作者: 吴磊, 范青华;
  • 基金资助:


Recent Progress of Metal/Metal Oxide Nanoparticles for Asymmetric Hydrogenation and Transfer Hydrogenation

Ji Yiganga,c, Wu Leia, Fan Qinghuab   

  1. a Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, China;
    b CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China;
    c Department of Life Sciences and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China
  • Received:2014-04-25 Published:2014-05-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372118, 21232008), the National Basic Research Program of China(No. 2010CB833300), “333 High Level Talent Project”, “QingLan Project” of JiangSu Province and the Fundamental Research Funds for the Central Universities (NJAU) (No. KYRC201211).

Metal/metal oxide nanoparticles for asymmetric hydrogenation and transfer hydrogenation have emerged as a frontier and evolved into a hot topic of asymmetric catalysis in recent years. Their catalytic modes resemble that of “nano-reactor”, where substrates diffuse through organic shells into catalytic active sites. Thus, high local catalyst concentration usually dramatically improves TON and TOF. In the case of nanoparticles as active sites, Orito’s platinum catalytic system received most extensive interests. Achievements have been made in chiral modifier structural modification, catalyst supports, reaction medium, nanoparticle morphology and catalytic mechanism. Moreover, other metal nanoparticles including palladium, rhodium, ruthenium, iridium and iron exhibited favorable catalytic efficiency in the asymmetric hydrogenation and transfer hydrogenation of alkenes, ketones and imines, especially for iridium and iron nanoparticles, ee values over 95% were obtained. In another case of metal/metal oxide nanoparticles as catalyst supports, comparable efficiency and enantioselectivity were observed to homogeneous catalysts, meanwhile, this protocol overcame the drawbacks of homogeneous catalysts with easier recovery and reuse. This review presents a brief overview on the recent progress in the asymmetric hydrogenation and transfer hydrogenation catalyzed by metal/metal oxide nanoparticles, as well as the related catalytic mechanism. However, there are still many challenges in this promising research field of metal/metal oxide nanoparticles for asymmetric catalysis. In addition to the continuous understanding of the catalytic mechanism, it is highly desirable to develop new types of metal/metal oxide nanoparticles with high efficiency, high enantioselectivity, and convenient recyclability.

Key words: transition metal, metal nanoparticles, asymmetric hydrogenation, asymmetric transfer hydrogenation, catalyst recycling