Acta Chim. Sinica ›› 2015, Vol. 73 ›› Issue (12): 1311-1314.DOI: 10.6023/A15040287 Previous Articles     Next Articles

Special Issue: 碳氢键官能团化



李远明, 贾凡, 马丽娜, 李志平   

  1. 中国人民大学化学系 北京 100872
  • 投稿日期:2015-04-27 发布日期:2015-06-15
  • 通讯作者: 李志平
  • 基金资助:


FeCl2-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

Li Yuanming, Jia Fan, Ma Lina, Li Zhiping   

  1. Department of Chemistry, Renmin University of China, Beijing 100872
  • Received:2015-04-27 Published:2015-06-15
  • Supported by:

    Project supported by the Fundamental Research Funds for the Central Universities and the Research Funds of Renmin University of China(No. 10XNL017).

The amidation reaction is an important process in both academia and industry for the synthesis of natural products, functional polymers, and pharmaceuticals. The development of new amidation methods for constructing such important class of organic compounds is still attracting considerable interests. We herein reported a general oxidative amidation of aldehydes with a variety of free primary or secondary amines using inexpensive iron(II) chloride as catalyst and tert-butyl hydroperoxide(TBHP) as oxidant. The present amidation reactions afford the corresponding secondary and tertiary amides in moderate to excellent yields. In addition, the amidations of benzimidazole and pyrazole were also achieved by the developed method.

Key words: iron catalysis, oxidative, amidation, aldehyde, amine