Acta Chimica Sinica ›› 1959, Vol. 25 ›› Issue (6): 383-390.
潘百川, 任云峰, 汪润瑛, 高怡生
PAN PEI-CHAUN, JEN YUN-FENG, WANG YUEN-YIN, KAO YEE-SHENG
The preparation of two kinds of nitrogen mustards related to local anesthetics was described.The compounds were (1).β-diethyl-amino-ethyl-p-bis-(2-chloroethyl) amino benzoate (Ⅳ, procaine-mustard), in which the p-amino-group of procaine (Ⅱ) was
replaced by bis-(2-chloroethyl) amino group (Ⅰ).Similarly, nitrogen mustards Ⅴ, Ⅶ, Ⅷ, Ⅸa, Ⅸb and Ⅸc related to thiocaine and other anesthetics have also been prepared.(2).N-β-diethylamino-ethyl 2-n-butoxy-6-bis-(2-chloroethyl)amino-cinchoninic acid amide
(ⅩⅥ, percaine-mustard), which was obtained by introducing Ⅰ to the molecule of percaine (ⅩⅢ).By doing so, the authors are in the hope to obtain a drug which, when appling directly to tumour tissue will not only act locally so as to prevent the normal tissue from being poisoned but will exert also the pain-relieving action.
PAN PEI-CHAUN, JEN YUN-FENG, WANG YUEN-YIN, KAO YEE-SHENG. TUMOUR CHEMOTHERAPY——Ⅱ.NITROGEN MUSTARDS RELATED TO LOCAL ANESTHETICS,PROCAINE,PERCAINE AND OTHERS[J]. Acta Chimica Sinica, 1959, 25(6): 383-390.
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