Acta Chimica Sinica ›› 1963, Vol. 29 ›› Issue (4): 260-265. Previous Articles     Next Articles

5-羥基色胺类似物——Ⅱ.2-甲基-3-(β-氨乙基)-5-甲氧基苯并呋喃及其N-取代衍生物的合成

周启霆, 嵇汝运   

  1. 中国科学院药物研究所
  • 收稿日期:1962-10-31 出版日期:1963-08-15 发布日期:2013-06-03

SEROTONIN ANALOGUES——Ⅱ. THE SYNTHESIS OF 2-METHYL-3-(β-AMINOETHYL)-5-METHOXY-BENZOFURAN AND ITS N-SUBSTITUTED DERIVATIVES

CHOW CHI-TING, KYI ZU-YOONG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1962-10-31 Online:1963-08-15 Published:2013-06-03

It was shown by Shaw and Woolley that in a series of closely related derivatives of serotonin, etherification of the phenolic hydroxyl and introduction of a methyl group in the 2-position favoured the anti-serotonin activity.In the present work, seven derivatives of 3-(β-aminoethyl)-5-β-droxy-berizofuran, an isosteric compound of serotonin, have been synthesized;each of them carries a methyl group on the 2-position and has its 5-hydroxy group methylated, the amino group on the side chain being free or substituted.