Acta Chimica Sinica ›› 1964, Vol. 30 ›› Issue (2): 166-175. Previous Articles     Next Articles

肿瘤的化学治疗ⅪⅩ.王浆的有效成分——10-羟基-癸烯酸的相似化合物及若干苯环取代肉桂酸的合成

潘百川, 翁尊尧   

  1. 中国科学院药物研究所
  • 收稿日期:1963-05-31 出版日期:1964-04-15 发布日期:2013-06-03

TUMOUR CHEMOTHERAPY ⅪⅩ. SYNTHESIS OF COMPOUNDS RELATED TO 10-HYDROXY-DECENOIC ACID AND A NUMBER OF RING SUBSTITUTED CINNAMIC ACIDS

PAN PEI-CHUAN, OWEN TSUNG-YAO   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-05-31 Online:1964-04-15 Published:2013-06-03

Recent investigations have shown that both antimicrobial[1] and antitumour[2] properties of Royal Je11y resulted solely from the presence of 10-hydroxy-decenoic acid (Ⅰ)[3,4].The present work reports the synthesis of m-(4-hydroxybutyl)-cinnamic acid (Ⅳa),a compound similar in structure with 10-hydroxy-decenoic acid,except that the 4,5,6-carbon atoms in the latter have been replaced by three adjacent carbon-atoms of a benzene ring.For the purpose of elucidating the relationship between也e biological activity and themical structure and of searching for more potent antitumour and antimicrobial agents,p-(4-hydroxybutyll-einnamic acid (Ⅳb),some hydroxy-alkoxy-cinnamic acids (Ⅴa-d) and other related compounds (Ⅵa-d,Ⅶa-b,Ⅷa-E and Ⅷg-p) were also prepared.