Acta Chimica Sinica ›› 1964, Vol. 30 ›› Issue (2): 166-175.
PAN PEI-CHUAN, OWEN TSUNG-YAO
Recent investigations have shown that both antimicrobial and antitumour properties of Royal Je11y resulted solely from the presence of 10-hydroxy-decenoic acid (Ⅰ)[3,4].The present work reports the synthesis of m-(4-hydroxybutyl)-cinnamic acid (Ⅳa),a compound similar in structure with 10-hydroxy-decenoic acid,except that the 4,5,6-carbon atoms in the latter have been replaced by three adjacent carbon-atoms of a benzene ring.For the purpose of elucidating the relationship between也e biological activity and themical structure and of searching for more potent antitumour and antimicrobial agents,p-(4-hydroxybutyll-einnamic acid (Ⅳb),some hydroxy-alkoxy-cinnamic acids (Ⅴa-d) and other related compounds (Ⅵa-d,Ⅶa-b,Ⅷa-E and Ⅷg-p) were also prepared.
PAN PEI-CHUAN, OWEN TSUNG-YAO. TUMOUR CHEMOTHERAPY ⅪⅩ. SYNTHESIS OF COMPOUNDS RELATED TO 10-HYDROXY-DECENOIC ACID AND A NUMBER OF RING SUBSTITUTED CINNAMIC ACIDS[J]. Acta Chimica Sinica, 1964, 30(2): 166-175.
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