Acta Chimica Sinica ›› 1964, Vol. 30 ›› Issue (2): 193-196. Previous Articles     Next Articles

延胡索素乙有关化合物的合成Ⅲ.2, 3, 9, 11-四甲氧基-5, 6, 13, 13a-四氢-8H-二苯并[a,g]喹诺里嗪的合成

宗汝实, 嵇汝运   

  1. 中国科学院药物研究所
  • 收稿日期:1963-06-28 出版日期:1964-04-15 发布日期:2013-06-03

THE SYNTHESIS OF TETRAHYDROPALMATIN ANALOGUES Ⅲ. THE SYNTHESIS OF 2, 3, 9, 11-TETRAMETHOXY-5, 6, 13, 13a-TETRAHYDRO-8H-DIBENZO [a, g] QUINOLIZINE

TSUNG JU-SHIH, KYI ZU-YOONG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-06-28 Online:1964-04-15 Published:2013-06-03

Corydalis B,a constituent of the Chinese plant CorydaLis ambihus,is a potent analgesic which also exhibits significant sedative activity.The chemical constitution of this alkaloid has been proved to be 2,3,9,10-tetramethoxy-5,6,13,13a-tetrahydro-8H-dibenzo [a,g] quinolizine (tetrahydropalmatin,Ⅰ).Pharmacological studies carried out in this institute revealed that replacement of the methoxy groups in I by other alkoxy or acyloxy groups caused substantial change in its pharmacological actions.