Acta Chimica Sinica ›› 1965, Vol. 31 ›› Issue (3): 211-217. Previous Articles     Next Articles

多环氮芥化合物的研究——Ⅰ.1-羰基-2[N-双(β-取代乙基)-氨次甲基]-1, 2, 3, 4-四氢菲的合成

褚季瑜, 張錦   

  1. 北京大学化学系
  • 收稿日期:1964-06-22 出版日期:1965-06-15 发布日期:2013-06-03

STUDIES ON NITROGEN MUSTARDS OF POLYCYCLIC COMPOUNDS Ⅰ. PREPARATION OF 1-KETO-2-[N-BIS(β-SUBSTITUTED ETHYL)-AMINOMETHYLENE]-1, 2, 3, 4-TETRAHYDROPHENANTHRENE

CHU CHI-YU, CHANG CHIN   

  1. Department of Chemistry, Peking University
  • Received:1964-06-22 Online:1965-06-15 Published:2013-06-03

When the Mannich reaction between 1-keto-1,2,3,4-tetrahydrophenanthrene (Ⅰ),diethanolamine hydrochloride and 36% aqueous solution of formaldehyde was carried out in 95% ethanol solution,three products were isolated.The main one is the hydrochloride of 1-keto-2-[N-bis (β-hydroxyethyl)-aminomethylene]-1,2,3,4-tetrahydrophenanthrene (Ⅱ),and two nitrogen-free by-products,namely 1-keto-2-methylene-1,2,3,4-tetrahydrophenan-threne (Ⅲ) and its dimer (Ⅴ).