Acta Chimica Sinica ›› 1965, Vol. 31 ›› Issue (3): 253-257.
TUNG TZENG-SHOU, TAI CHANG-SHIH
γ-Aryl-γ-hydroxy-propylamines have been synthesized as follows:In the presence of polyphosphoric acid,β-phthalimidopropanoic acid (Ⅰ) was condensed with anisol or pyrocatechol dimethylether to give the corresponding aryl (β-phthalimido) propanones(Ⅱ) in good yields.Compounds Ⅱ were hydrolysed to amino-ketones (Ⅲ),which were then reduced to Ⅳ on the one hand,and acetylated to amines Ⅴ on the other hand.When the latter compounds were reduced by sodium borohydride,the corresponding γ-aryl-γ-hydroxy-propylamines (Ⅵ) were obtained.
TUNG TZENG-SHOU, TAI CHANG-SHIH. SYNTHESIS OF γ-ARYL-γ-HYDROXY-PROPYLAMINES[J]. Acta Chimica Sinica, 1965, 31(3): 253-257.
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