Acta Chimica Sinica ›› 1988, Vol. 46 ›› Issue (5): 478-482. Previous Articles     Next Articles

Original Articles

模拟细胞色素P-450的仿生氧化反应的研究 I:氯合5,10,15,20-四苯基卟吩合铁(III)催化下不同亚碘酰芳烃及其衍生物的结构对环己烷充氧化反应的影响

朱申杰;张春豪   

  1. 南开大学化学系
  • 出版日期:1988-05-15 发布日期:1988-05-15

Study of biomimetic oxidation catalyzed by the model compound of cytochrome P-450 I: The influence of the structure of some substituted iodosobenzene derivatives on the oxygenation of cyclohexane catalyzed by 5,10,15,20-tetrapenylporphinatoiron chloride

ZHU SHENJIE;ZHANG CHUNHAO   

  • Online:1988-05-15 Published:1988-05-15

The biomimetic monooxygenation of cyclohexane with some substituted iodosobenzene and iodosobenzene derivatives catalyzed by 5,10,15,20-tetraphenylporphinatoiron chloride [TPPFe(III)Cl] was studied. The electronic effect of para substituents and both the steric and electronic effect of meta substituents in the substituted iodosobenzene were well linear correlated to the yields of cyclohexanol. When either phenyliodosyl diacetate or phenyliodosyl tosylate was used as oxidant, the yields of cyclohexanol were low, close to the case when iodosobenzoic acid or o-iodosobenzoic ester was used (near to zero). All these compounds were much weaker oxidants than iodosobenzene. It may be suggested that the intermol. and intramol. bonding structure-I(OH)OCO- in iodosobenzoic acid and o-iodosobenzoic ester were present. Besides, the effects of the structure of oxygen donor to the activity of oxygenation was discussed.

Key words: PORPHINE P, CHLORO COMPLEX, BENZENE P, IRON COMPLEX, ORGANOIODINE COMPOUNDS, BENZENECARBOXYLIC ACID P, CYTOCHROME, ELECTRONIC EFFECT, BIONICS, CYCLOHEXANE

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