Acta Chimica Sinica ›› 1992, Vol. 50 ›› Issue (8): 817-821. Previous Articles     Next Articles

Original Articles

光学活性α-取代(2-吡啶基)甲胺的对映选择性合成

宓爱巧;肖勋;吴兰均;蒋耀忠   

  1. 中国科学院成都有机化学研究所
  • 出版日期:1992-08-15 发布日期:1992-08-15

Enantioselective syntheses of optically active a-substituted-(2-pyridyl)methyiamines

MI AIQIAO;XIAO XUN;WU LANJUN;JIANG YAOZHONG   

  • Online:1992-08-15 Published:1992-08-15

Optically active a-substituted (2-pyridyl)methylamines I (R = Me, Me2CH, allyl, PhCH2, 4-MeOC6H4CH2) were obtained by using 2-hydroxypinan-3-one as a chiral auxiliary, condensed with 2-aminomethyl pyridine to form a chiral ketimine and followed by asym. alkylation with different RX (X = Br, Cl, iodo) and removal of the auxiliary. The e.e. values of I were 89-98%. The transition model was successful in explaining the results.

Key words: ALKALOID, INFRARED SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, NMR SPECTROMETRY, AMINOPYRIDINE

CLC Number: