Enantioselective syntheses of optically active a-substituted-(2-pyridyl)methyiamines

Acta Chimica Sinica ›› 1992, Vol. 50 ›› Issue (8): 817-821. Previous Articles Next Articles

Original Articles

光学活性α-取代(2-吡啶基)甲胺的对映选择性合成

宓爱巧;肖勋;吴兰均;蒋耀忠

中国科学院成都有机化学研究所

发布日期:1992-08-15

Enantioselective syntheses of optically active a-substituted-(2-pyridyl)methyiamines

MI AIQIAO;XIAO XUN;WU LANJUN;JIANG YAOZHONG

Published:1992-08-15

Abstract

Optically active a-substituted (2-pyridyl)methylamines I (R = Me, Me2CH, allyl, PhCH2, 4-MeOC6H4CH2) were obtained by using 2-hydroxypinan-3-one as a chiral auxiliary, condensed with 2-aminomethyl pyridine to form a chiral ketimine and followed by asym. alkylation with different RX (X = Br, Cl, iodo) and removal of the auxiliary. The e.e. values of I were 89-98%. The transition model was successful in explaining the results.

Key words: ALKALOID, INFRARED SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, NMR SPECTROMETRY, AMINOPYRIDINE

CLC Number:

O621

Cite this article

MI AIQIAO;XIAO XUN;WU LANJUN;JIANG YAOZHONG. Enantioselective syntheses of optically active a-substituted-(2-pyridyl)methyiamines[J]. Acta Chimica Sinica, 1992, 50(8): 817-821.

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光学活性α-取代(2-吡啶基)甲胺的对映选择性合成

Enantioselective syntheses of optically active a-substituted-(2-pyridyl)methyiamines

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