Acta Chimica Sinica ›› 2000, Vol. 58 ›› Issue (10): 1186-1187. Previous Articles     Next Articles

Original Articles

新三羟基-西松烯二萜内酯

杨若林;曾陇梅;苏镜娱;李红   

  1. 中山大学化学系.广州(510275)
  • 出版日期:2000-10-15 发布日期:2000-10-15

A new trihydroxylated cembrenolide diterpene

Yang Ruolin;Zeng Longmei;Su Jingyu;Li Hong   

  1. Zhongshan Univ., Dept Chem.Guangzhou(510275)
  • Online:2000-10-15 Published:2000-10-15

Four cembrenolides (1~4) were isolated from the soft coral sinularia capillosa collected around Sanya, Hainan Island, China. Compound (1), C~2~0H~3~2O~5, m.p.158~160℃, [α]~D^2^5+42.8°(c 0.05, EtOH) is a new compound. Its structure was elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 was determined to be 1R^*, 4R^*, 5S^*, 12S^*, 13R^* mainly by NOESY and NOE difference spectra. Compound (4), flexibilide, exhibited potent cytotoxicity toward HepA and EAC cell lines.

Key words: SOFT CORAL, SPECTROMETRIC ANALYSIS

CLC Number: