Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (4): 447-455.     Next Articles

Original Articles

ALS抑制剂合理分子设计的研究进展

杨光富;杨华铮   

  1. 华中师范大学农药化学研究所;南开大学元素有机化学研究所.天津(300071); 南开大学元素有机化学国家重点实验室
  • 出版日期:2001-04-15 发布日期:2001-04-15

Research developoment of rational molecular design of ALS inhibitors

Yang Guangfu;Yang Huazheng   

  1. Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071)
  • Online:2001-04-15 Published:2001-04-15

Acetolactate synthase (ALS) has been a very attractive target for herbicides for the last decade. There are several ALS inhibitors in commercial use spanning the world-wide market. In this paper,the research developoment of rational molecular design of ALS inhibitors is reviewed from five aspects: (1) structure characterization of ALS inhibitors, (2) QSAR and 3D - QSAR analyses, (3) nonlinear QSAR analysis, (4) action model of ALS inhibitors, (5) molecular design of novel ALS inhibitors.

Key words: INHIBITOR, MOLECULAR DESIGN

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