Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (4): 594-599. Previous Articles     Next Articles

Original Articles

5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-硫乙酰腙类 衍生物的合成及生物活性 研究

杨光富;刘祖明;陆爱红;庄农波   

  1. 华中师范大学农药研究所
  • 出版日期:2001-04-15 发布日期:2001-04-15

Syntheses and biological activity of 5,7-dimethyl- 1,2,4-triazolo[1, 5-a]pyrimidine-2-thioacetohydrazones

Yang Guangfu;Liu Zuming;Lu Aihong;Zhuang nongbo   

  • Online:2001-04-15 Published:2001-04-15

Sixteen novel 5,7-dimethyl-1,2,4-triazolo[1,5-a] pyrimidine-2 thioacetohydrazone derivatives have been designed and synthesized based on the starting material 2-mercapto-5,7-dimethyl-1,2,4-triazolo [1,5-a]pyrimidine. All compounds synthesized are identified by 1^H NMR, MS and elemental analyses. Cis/trans isomers of the compounds are observed in solutions by analyzing the NMR spectroscopy and the chemical shifits of the cis/trans isomers are assigned by molecular mechanics method. Preliminary bioassay indicates that all the compounds display herbicidal activity to some extent and excellent fungicidal activity against rhizoctonia solani.

Key words: PYRRODIAZOLE P, PYRIMIDINE P, HYDRAZONE P, BIOLOGICAL ACTIVITY, PROTON MAGNETIC RESONANCE SPECTROMETRY, MASS SPECTROGRAPHY, CHEMICAL SHIFT, PESTICIDES

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