Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (5): 746-750. Previous Articles     Next Articles

Original Articles

手性卟啉化合物聚集体与DNA 的相互作用: 电子吸收光谱 和圆二色光谱研究

彭小彬;蔡洁;袁高清   

  1. 华南理工大学应用化学系.广州
  • 出版日期:2001-05-15 发布日期:2001-05-15

The interaction between the assembly of chiral zinc (Ⅱ) prophyrin and DNA: Electron absorption spectrum and CD spectrum studies

Peng Xiaobin;Cai Jie;Yuan Gaoqing   

  1. S China Univ of Polytechnol., Dept of Appl Chem.Guangzhou
  • Online:2001-05-15 Published:2001-05-15

Using electron absorption spectra and CD( circular dichroism) spectra, we studied the interaction between the assembly of chiral acid modified porphyrinatozinc (Ⅱ)( Thr--TPPZn ) and DNA. The helical assembly of Thr---TPPZn can bind to DNA. The amino acid residue of the assembly of L-----Thr ---TPPZn forms hydrogen bonds with the ohosphate chain of DNA, and the binding belongs to external type. As to the assembly of D----Thr ----TPPZN, the porphyrin unit formsπ-π stacking with the base pair of DNA besides the above mentioned hydrogen bonding. In this case, the binding is a partial intercalation. The reason for the different binding mode is that the assembly of L amino acid modified porphyrinatozinc ( Ⅱ) is left -- handed helical, which cannot match the right --handed helical of DNA, while the assembly of D--amino acid modified porphrinatozinc (Ⅱ) is right --handed helical that can match the helical of DNA.

Key words: PORPHYRIN, AGGREGALES, DEOXYRIBONUCLEIC ACID, INTERACTIONS

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