Acta Chimica Sinica ›› 2002, Vol. 60 ›› Issue (2): 334-337. Previous Articles     Next Articles

Original Articles

豆荚软珊瑚Lobophytum sp. 的次生代谢产物研究

何细新;苏镜娱;曾陇梅;杨小平;梁永钜   

  1. 中山大学化学化工学院.广州(510275);中山医科大学肿瘤研究所.广州(510000)
  • 出版日期:2002-02-15 发布日期:2002-02-15

Studies on the secondary metabolite of the soft coral Lobophytum sp.

He Xixin;Su Jingyu;Zeng Longmei;Yang Xiaoping;Liang Yongju   

  1. Zhongshan Univ, Sch Chem & Chem Engn.Guangzhou(510275);Sun Yat-sen Univ Med Sci., Cancer Res Inst.Guangzhou(510000)
  • Online:2002-02-15 Published:2002-02-15

Five steroidal glycsides (1)~(5) have been isolated from the soft coral Lobophytum sp. , collected from Sanya Bay, Hainan Island. Base on the spectroscopic methods, their structures were determined to be 3'-O-acetyl-4-O-[β-D-xylo- pyranosyl-oxy]-pregn-20-en-3β, 4α-diol (1), 4-O-[β-D-xylo- pyranosyloxy]-pregn-20-en-β, 4α-diol (2), 4'-O- acetyl-4-O- [β-D-xylo-pyranosyl-oxy]-pregn-20-en-3β, 4α-diol(3), 4'-O-acetyl-4-O-[β-D-arabino-pyranosyl-oxy]-pregn-20-en-3β, 4α- diol (4), and 4-O-[β-D-arabinopyranosyl-oxy]-pregn-20-en- 3β, 4α- diol (5). Among them, 1 is a new compound. Bioassay showed that 1, 2 and 5 displayed cytotoxicity against human SKMG-4, Hep-G2 and CNE2 cell lines in vitro.

Key words: CYTOTOXICITY TEST, STEROL, SPECTROMETRIC ANALYSIS, GLYCOSIDE, SOFT CORAL, METABOLITE

CLC Number: