Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (1): 47-52. Previous Articles     Next Articles

混合碳链烷基聚葡糖苷中相微乳液的研究

柴金岭1,2, 李东祥1, 李干佐1, 梁芳珍2, 张高勇1, 夏瑞3   

  1. 1. 山东大学胶体与界面化学教育部重点实验室, 济南, 250100;
    2. 山东师范大学化学系, 济南, 250014;
    3. 北京药品检验所, 北京, 100035
  • 收稿日期:2003-03-20 修回日期:2003-09-01 出版日期:2004-01-14 发布日期:2014-01-26
  • 通讯作者: 李干佐 E-mail::E-mail:coliw@sdu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.20243005,20243006)和贵州省省长专项基金黔科教办(2001)6号资助项目.

Studies on the Middle-Phase Microemulsions of Alkyl Polyglucosides with Mixed Hydrocarbon Chain

CHAI Jin-Ling1,2, LI Dong-Xiang1, LI Gan-Zuo1, LIANG Fang-Zhen2, ZHANG Gao-Yong. XIA Rui1   

  1. 1. Key Laboratory for Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100;
    2. Department of Chemistry, Shandong Normal University, Jinan 250014;
    3. Beijing Municipal Institute of Drug Controls, Beijing 100035
  • Received:2003-03-20 Revised:2003-09-01 Online:2004-01-14 Published:2014-01-26

The phase behavior of the middle-phase microemulsion for the quaternary system of the mixed-chain alkyl polyglucoside (C8/10APG or C12/14APG)/1-butanol/n-octane/water has been studied with Winsor phase diagram, δ-γ fishlike and modified ε-β fishlike phase diagrams. A series of phase changes Winsor I→Ⅲ→Ⅱ were observed from above three kinds of phase diagrams with increasing the concentration of alcohol. It was observed from the Winsor phase diagram that the phase types, the phase volumes and the concentrations of alcohol at the start point and end point of the Winsor microemulsion formation change with the increase of the concentration of alcohol. From the δ-γ fishlike phase diagram, some important parameters were calculated, such as the mass fraction of 1-butanol in the hydrophile-lipophile balanced interfacial layer, AS, the coordinates of the start point and the end point of the Winsor microemulsion formation, and the solubilities of APG and 1-butanol in n-octane phase. The modified ε-β fishlike phase diagram was presented for the first time by us. With the ε-β fishlike phase diagram, the above experimental phenomena were observed and the physico-chemical parameters were calculated precisely. The ε-β fishlike phase diagram has some advantages over the Winsor and δ-γ fishlike phase diagrams in visual observations of the phase changes, and calculation of the related physico-chemical parameters.

Key words: middle-phase microemulsion, fishlike phase diagram, alkyl polyglucoside, solubilization