Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (22): 2221-2224. Previous Articles     Next Articles

Original Articles

脱氧核糖核酸一级序列特殊碱基组合及相关性研究

张宝华, 王海水, 许禄*   

  1. (中国科学院长春应用化学研究所 长春 130022)
  • 收稿日期:2006-04-10 修回日期:2006-06-06 出版日期:2006-11-28 发布日期:2006-11-28
  • 通讯作者: 许禄

Studies on Special Combination of Bases and Relationships in De-oxynucleic Acid Primary Sequences

ZHANG Bao-Hua; WANG Hai-Shui; XU Lu*   

  1. (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)
  • Received:2006-04-10 Revised:2006-06-06 Online:2006-11-28 Published:2006-11-28
  • Contact: XU Lu

There are 16 ways for 4 kinds of bases to combine as a pair within DNA primary sequence (for example, ct, ag, cg, tc and so on.), and the frequencies of occurrences of different pairs in sequence are not the same. Especially, the frequency of cg is very low. In this article, we take the frequency of cg as parameter and calculate the molecular connectivity indices. Then, we compare the sequences of 10 species based on the indices and group them into different classes. The results agree with the phylogenetic tree satisfactorily.

Key words: DNA primary sequence, cg pair of bases, molecular connectivity indices, similarity analysis