Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (7): 645-650. Previous Articles     Next Articles

Original Articles

四-(对氨基苯基)钴卟啉-NO配合物的合成及NO释放效能和生物学活性

鲁燕妮, 肖丽波, 杨琴, 冯清*   

  1. (华中科技大学化学系 武汉 430030)
  • 收稿日期:2006-06-06 修回日期:2006-11-07 出版日期:2007-04-14 发布日期:2007-04-14
  • 通讯作者: 冯清

Synthesis, NO Releasing Efficiency and Bioactivities of Complex Nitrosyl meso-Tetrakis(4-aminophenyl)porphyrin Cobalt

LU Yan-Ni; XIAO Li-Bo; YANG Qin; FENG Qing*   

  1. (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430030)
  • Received:2006-06-06 Revised:2006-11-07 Online:2007-04-14 Published:2007-04-14
  • Contact: FENG Qing

To synthesize nitrosyl meso-tetrakis(4-aminophenyl)porphyrin cobalt (TAPP-Co-NO) as NO donor, the NO-releasing property of TAPP-Co-NO in aqueous solution was studied by diazotization at room temperature. Next, the relaxation of TAPP-Co-NO was investigated on isolated aorta pectoralis circle in the rabbit. Finally, eighteen rats were randomized into two groups. The treatment group was injected venously with 0.5 mL of TAPP-Co-NO mixed DMSO, and the control group was given with 0.5 mL of DMSO. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rates (HR) were measured before and after administration. NO-releasing ratio of TAPP-Co-NO was 63.17%. TAPP-Co-NO shifted methoxamine cumulative dose-response curves rightward im-paralleled and reduced the maximal response (Emax), the reduced percentage was 55.7%. For the treatment group, the blood pressure of rats began to decrease at the time of 5 s after the administration. The blood pressure of rats reached minimum at the time of 10 s, then increased gradually, and finally, approached normal blood pressure at 60 s. For the control group, the blood pressure of the rats was not changed after employing the DMSO. The results show that NO-releasing ratio of the TAPP-Co-NO was relatively high and it could decrease blood pressure instantaneously.

Key words: TAPP-Co-NO, NO donor, isolated vascular circle, depressurization