Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (05): 508-514. Previous Articles     Next Articles

Full Papers


杨占娴, 宫永宽   

  1. (合成与天然功能分子化学教育部重点实验室 西北大学化学与材料科学学院 西安 710069)
  • 投稿日期:2010-07-18 修回日期:2010-11-11 发布日期:2010-11-25
  • 通讯作者: 宫永宽
  • 基金资助:


Preparation and Property of Liposome with Isonicotinyl Hydrazide Phospholipid Derivative for High Encapsulation Efficiency

YANG Zhan-Xian, GONG Yong-Kuan   

  1. (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi an 710069)
  • Received:2010-07-18 Revised:2010-11-11 Published:2010-11-25

Isonicotinyl hydrazide (INH) was chosen as a model drug, and was covalently attached to glyceryl phosphatide as the hydrophobic moieties of the phospholipid derivative. Isonicotinyl hydrazide phospholipid derivative liposome was prepared by thin-film hydration and sonication method. Drug encapsulation efficiency and drug to lipid molar ratio of the liposome were increased from 2% to nearly 100% and from 0.1~0.3 to 2.0 respectively. Liposomes with different sizes were prepared by controlling concentration of the phospholipid derivative and sonication time. The liposomes showed remarkable controlled drug release property when compared with a free drug. This novel liposome provides a new way for encapsulating drugs more especially.

Key words: liposome, encapsulation efficiency, isoniazid, phospholipid derivative, controlled release

CLC Number: