Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (12): 1431-1437. Previous Articles     Next Articles

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  1. (1贵州省大环化学及超分子化学重点实验室 贵州大学 贵阳 550025)
    (2贵州大学化学与化工学院 贵阳 550025)
  • 投稿日期:2010-10-13 修回日期:2011-01-05 发布日期:2011-02-24
  • 通讯作者: 董南
  • 基金资助:


Influence of Cucurbit(n=7,8)uril on the Solubility and Stability of Chlorambucil

Dong Nan*,1,2 Wang Xiulin2 Pan Jinpin2 Tao Zhu1,2   

  1. (1 Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025)
    (2 School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025)
  • Received:2010-10-13 Revised:2011-01-05 Published:2011-02-24

The effects of cucurbit(n=7,8)uril (Q[7,8]) on the solubility and stability of chlorambucil (CHL) have been investigated. The results from high performance liquid chromatography indicated that in the presence of 2.0×10-4 mol•L-1 Q[7], there is a 4-fold increase in the stability of chlorambucil at 37 ℃, pH 2.0, while a greater 15-fold increase in the presence of 8.0×10-5 mol•L-1 Q[8] under same conditions. Aqueous solubility of CHL is increased more than 6-fold or 36-fold increase in the presence of 1.0×10-4 mol•L-1 Q[8] or 1.0×10-3 mol•L-1 Q[7] respectively under conditions where degradation is minimized (3 ℃, pH 2.0). Stability constants of the CHL complex with Q[7,8] were determined kinetically and spectrophotometrically under various experimental conditions assuming 1∶1 inclusion complex formation. 1H NMR further confirmed that Q[7,8] could form complexes with CHL and the possible interaction models were proposed.

Key words: cucurbit(n=7,8)uril, chlorambucil, stability, aqueous solubility, interaction