Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (19): 2228-2234. Previous Articles     Next Articles

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  1. (1南京中医药大学 南京210046)
    (2东南大学化学化工学院 南京211189)
    (3南京师范大学分析测试中心 南京210097)
    (4南京师范大学化学与环境科学学院 南京210097))
  • 投稿日期:2011-01-14 修回日期:2011-05-17 发布日期:2011-06-09
  • 通讯作者: 吴启南
  • 基金资助:


Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin

Xu Fei1 Zhang Linqun2,3 He Liwei1 Gu Wei1 Fang Fang1 Wu Qinan*,1 Zhao Bo*,4   

  1. (1 Nanjing University of Chinese Medicine, Nanjing 210046)
    (2 School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189)
    (3 Center for Analysis and Testing, Nanjing Normal University, Nanjing 210097)
    (4 College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097)
  • Received:2011-01-14 Revised:2011-05-17 Published:2011-06-09

The anti-tumor effect of Traditional Chinese Medicine Alisma may be related to the change of protein components in serum. The molecular interaction mechanism of Alisols with Human Serum Albumin (HSA) was investigated by fluorescence and circular dichroism spectra in combination with molecular modeling under the simulated physiological conditions in the paper. Molecular modeling results are in agreement with the experimental results revealed that the binding of Alisol B 23-acetate and HSA was much more stronger than that with Alisol A 24-acetate, indicating that the difference is related to the structure of the side chain. The conclusion should be of great assistant for studying formulations of Alisma and the anti-tumor mechanism.

Key words: alisol B 23-acetate, alisol A 24-acetate, fluorescence spectra, circular dichroism spectra, molecular modeling