Acta Chimica Sinica ›› 2003, Vol. 61 ›› Issue (12): 2029-2032. Previous Articles     Next Articles

Original Articles

三核铜配合物[Cu_3L_2](ClO_4)_2(H_2L=1,3-双(2-羟基-1-苯基-亚甲基)-丙烷)的合成与对pBR322DNA的切断作用

沈鹤柏;杨永桃;杨仕平;蒯丽衡;姜霁;陈红梅   

  1. 上海师范大学生命与环境科学学院
  • 出版日期:2003-12-15 发布日期:2003-12-15

Synthesis of Trinuclear Copper (II) Complex [Cu_3L_2] (ClO_4)_2 and Its Cleavage of pBR332 DNA

Shen Hebai;Yang Yontao;Yang Shiping;Kuai Liheng;Jiang Ji;Chen Hongmei   

  1. College of Life and Environment Science, Shanghai Normal University
  • Online:2003-12-15 Published:2003-12-15

A trinudear copper (II) complex with Schiff-base ligand, [Cu_3L_2] (ClO_4)_2, [ H_2L = 1,3-bis(2-hydroxylbenzoylimino)propane], was synthesized and characterized by X-ray crystal diffraction analysis. The interaction of the complex with pBR322 DNA has been investigated by agaiose gel electrophoresis. The complex has been found to promote cleavage of pBR322 DNA from supercoiled form I to the open circular form II and to linearized form III , showing that the complex has high cleaving efficiency to DNA. The UV spectroscopy demonstrates that the complex can bind to DNA by partial intercalation.

Key words: COPPER COMPLEX, SCHIFF BASE, XRD, CRYSTAL STRUCTURE, UV

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