Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (18): 1713-1719. Previous Articles     Next Articles

Original Articles



  1. (电子科技大学应用物理系 成都 610054)
  • 投稿日期:2004-12-17 修回日期:2005-05-31 发布日期:2010-12-10
  • 通讯作者: 孙久勋

Study on Osmotic Pressure of Aqueous Bovine Serum Albumin-NaCl Solutions Based on Analytical Ross Variational Perturbation Theory

XUE Xin-Ying, SUN Jiu-Xun*, MO Wen-Juan   

  1. (Department of Applied Physics, University of Electronic Science and Technology, Chengdu 610054)
  • Received:2004-12-17 Revised:2005-05-31 Published:2010-12-10
  • Contact: SUN Jiu-Xun

Three-Yukawa potential was used to describe the attractive dispersion, soft-sphere repulsion and the screened static-electric repulsion interactions between protein molecules respectively instead of the hardcore two-Yukawa potential. A simple analytical equation of state has been derived based on the Ross perturbation theory to overcome the difficulty exsiting in mean-sphere-approximation (MSA) reported in literature. The equation of state has been applied to study osmotic pressures for aqueous bovine serum albumin (BSA)-NaCl solutions at various values of pH and concentration. The results show that the precision of new theory is superior to the theory recently developed by Lin Yang-Zheng, with only one more independent parameter. And it is shown that the new soft-sphere theory is more reasonable than Lin Yang-Zheng’s one and more appropriate to the protein systems with large molecular weight.

Key words: protein-electrolyte aqueous solution, osmotic pressure, Ross perturbation theory, analytical equation of state, three Yukawa potential