Acta Chimica Sinica ›› 1982, Vol. 40 ›› Issue (12): 1137-1141. Previous Articles     Next Articles

钩吻生物碱的研究——Ⅰ.钩吻素己的结构

杜秀宝, 戴韵华, 张常麟, 卢树林, 刘助国   

  1. 中国人民解放军药物化学研究所 北京
  • 收稿日期:1981-05-28 出版日期:1982-12-15 发布日期:2013-06-03
  • 通讯作者: 杜秀宝

STUDIES ON THE GELSEMIUM ALKALOIDS Ⅰ. THE STRUCTURE OF GELSENICINE

DU XIU-BAO, DAI YUN-HUA, ZHANG CHANG-LIN, LU SHU-LIN, LIU ZEU-GUO   

  1. Institute of Medicinal Chemistry of PLA, Beijing
  • Received:1981-05-28 Online:1982-12-15 Published:2013-06-03

Two new alkaloids, named gelsenicine and gelsenidine respectively, have been isolated from Chinese gelsemium (Gelsemzum elegans Benth.) by alnminnm oxide column chromatography and preparative TLC on silica gel GF254.Gelsenicine, C21H24N2O3.m.p.171~173℃, has been identified as,through spectroscopic analyses (UV, IR, NMR, MS) and chemical reactions.The structure of gelsenidine, C21H24N2O3, m.p.143-145℃, is being determined.From this plant, we have also isolated six known alkaloids: konmine, koumini-dine, koumicine, koumidine, geleemine and N1-methogygelsemine.The last one was fiist isolated from Gelsemium sempervirens Ait., bnt its isolation from Gelsemium elegans Benth, has not been reported.On the basis of the high resolution mass spectral data the molecular formula of koumicine, previously reported to be C20H30N2O3, is now revised to C21H24N2O3, m.p.252-254℃(dec.).