有机化学 ›› 2012, Vol. 32 ›› Issue (01): 19-29.DOI: 10.6023/cjoc1104231 上一篇    下一篇

综述与进展

手性氨基酸及其衍生物配体在酮不对称氢转移反应中的应用进展

李小娜, 张鹏亮, 段凯, 王家喜   

  1. 河北工业大学化工学院 天津 300130
  • 收稿日期:2011-04-23 修回日期:2011-06-10 出版日期:2012-01-25 发布日期:2011-08-24
  • 通讯作者: 王家喜 E-mail:jwang252004@126.COM
  • 基金资助:

    河北省自然科学基金(No. B2011202087)资助项目.

Recent Advance of Amino-acids and Their Derivatives as Chiral Ligands in Asymmetric Transfer Hydrogenation of Ketones

Li Xiaona, Zhang Pengliang, Duan Kai, Wang Jiaxi   

  1. School of Chemical Engineering, Hebei University of Technology, Tianjin 300130
  • Received:2011-04-23 Revised:2011-06-10 Online:2012-01-25 Published:2011-08-24
  • Contact: WANG Jia-Xi E-mail:jwang252004@126.COM
  • Supported by:

    Project supported by the Natural Science Foundation of Hebei Province (No. B2011202087).

前手性酮的不对称氢转移反应(ATH)是获得手性醇的重要方法. 近年来氨基酸及其衍生物在金属Ru, Rh, Ir 催化酮的ATH 中的应用引起人们关注. 就氨基酸、氨基酸酰胺、氨基酸硫代酰胺、氨基酸羟胺酸、氨基酸酰肼、氨基醇及氨基酸羟基酰胺等为配体的金属络合物在ATH 中的催化性能进行了综述.

关键词: 手性氨基酸, 氨基酸衍生物, 氨基酸金属络合物, 不对称氢转移

The asymmetric transfer hydrogenation (ATH) reaction of prochiral ketones is an important method to produce chiral alcohols. Recently, the application of chiral amino acids and their derivatives as ligands in ATH of prochiral ketones promoted by the ruthenium, rhodium or iridium complexes have been attracted more attentions. Herein the catalytic properties of amino acids, amino acid based amides, thioamides, hydroxamic acids, hydrazides, amino alcohols and hydroxy amides as ligands in the ruthenium, rhodium or iridium catalyzed ATH of prochiral ketones have been overviewed.

Key words: chiral amino acid, derivative of amino acid, metal complex of amino acid, asymmetric transfer hydrogenation