有机化学 ›› 2016, Vol. 36 ›› Issue (1): 1-42.DOI: 10.6023/cjoc201509006 上一篇    下一篇

综述与进展

唑类超分子药物研究与应用 2017-2018 Awarded

程宇, 王辉, Dinesh Addla, 周成合   

  1. 西南大学化学化工学院 生物有机与药物化学研究所 重庆市高校应用化学重点实验室 重庆 400715
  • 收稿日期:2015-09-05 修回日期:2015-10-04 出版日期:2016-01-25 发布日期:2015-10-13
  • 通讯作者: 周成合 E-mail:zhouch@swu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21172181, 21372186, 国际合作项目81450110451)、重庆市自然科学基金(No. CSTC2012jjB10026)、高等学校博士学科点专项科研基金(博导类)(No. SRFDP 20110182110007)资助项目.

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng Yu, Wang Hui, Addla Dinesh, Zhou Chenghe   

  1. Key Laboratory of Applied Chemistry of Chongqing Municipality, Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715
  • Received:2015-09-05 Revised:2015-10-04 Online:2016-01-25 Published:2015-10-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China [(Nos. 21172181, 21372186, 81450110451 (International (Regional) Cooperation and Exchange Program)], the Natural Science Foundation of Chongqing City (No. CSTC2012jjB10026) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. SRFDP 20110182110007).

基于非共价键力的超分子化学发展非常迅猛, 在化学、物理、材料科学、信息科学以及医药等领域显示出广泛的应用前景和巨大的开发价值. 唑类化合物如咪唑、噻唑、噁唑、吡唑、三唑、四唑和咔唑等具有特殊的含氮芳杂环结构, 可通过非共价键力与无机物和/或有机物形成络合物超分子, 表现出广泛的生物活性. 近些年来, 唑类超分子在医药领域发展迅速, 已成为研究热点领域之一. 结合本课题组相关研究工作, 参考国内外近五年文献, 系统地综述了唑类超分子作为药物在抗癌、抗细菌、抗真菌、杀虫、抗糖尿病、降血压、消炎等方面的研究与应用, 并展望了其未来可能的发展趋势.

关键词: 超分子, 唑, 抗癌, 抗细菌, 抗真菌, 抗糖尿病, 降血压, 消炎

Noncovalent bond forces-based supramolecular chemistry grows quite rapidly and has been revealed to have extensively potential applications and huge development values in chemistry, physics, materials and information science, medicine and so on. Azole compounds such as imidazoles, thiazoles, oxazoles, pyrazoles, triazoles, tetrazoles and carbazoles containing special nitrogen aromatic heterocyclic structure, can exert non-covalent forces to form supramolecular complexes with inorganic and/or organic compounds and exhibit broad biological activity. In recent years, heterocyclic azole-based supramolecular complexes have been expeditiously expanding in the field of medicine, and have become a quite hot topic. Combined with our work and referring to other literature in recent 5 years, this paper systematically reviews the researches and applications of azole-based supermolecules as medicinal agents including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory drugs and other ones. Finally, the perspectives of the future development of azole-based supermolecules as medicinal agents are also presented.

Key words: supermolecule, azole, anticancer, antibacterial, antifungal, antidiabetic, antihypertensive, anti-inflammatory