有机化学 ›› 2017, Vol. 37 ›› Issue (4): 920-924.DOI: 10.6023/cjoc201610046 上一篇    下一篇

研究论文

FeCl3作用下烯基醇的碘代环醚化反应:一种合成碘代环醚的简便方法

范卫永a, 余磊b, 彭湘君b, 刘良先a   

  1. a. 赣南师范大学化学化工学院 赣州 341000;
    b. 赣南医学院药学院 赣州 341000
  • 收稿日期:2016-10-31 修回日期:2016-12-23 出版日期:2017-04-25 发布日期:2017-01-10
  • 通讯作者: 彭湘君, 刘良先 E-mail:pengxiangjun99@126.com;lxliu@xmu.edu.cn

In the Presence of FeCl3 Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers

Fan Weiyonga, Yu Leib, Peng Xiangjunb, Liu Liangxiana   

  1. a. Department of Chemistry and Biology, Gannan Teachers' College, Ganzhou 341000;
    b. School of Pharmaceutical Science, Gannan Medical University, Ganzhou 341000
  • Received:2016-10-31 Revised:2016-12-23 Online:2017-04-25 Published:2017-01-10
  • Contact: 10.6023/cjoc201610046 E-mail:pengxiangjun99@126.com;lxliu@xmu.edu.cn

研究了在温和的反应条件和FeCl3作用下,各种烯基醇与碘发生分子内碘代环化反应生成碘代环醚,收率优良. 该反应具有操作简单、底物适应广、反应快和碘用量少等特点,是现有制备碘代环醚方法的良好补充.

关键词: 分子内碘代环醚化反应, 三氯化铁, 烯基醇

In the presence of FeCl3 reaction of alkenols with iodine resulted in intramolecular addition of hydroxyl to alkenol to produce a wide range of iodocyclic ethers in good to excellent yields under mild reaction conditions. The advantages of our procedure include a decreased amount of iodine as well as short reaction times. The broad scope, mild reaction conditions, and experimental ease of this transformation have made it a valuable alternative to current available methods for the preparation of iodocyclic ethers.

Key words: intramolecular iodoetherification, iron trichloride, alkenol