有机化学 ›› 2017, Vol. 37 ›› Issue (4): 824-840.DOI: 10.6023/cjoc201611017 上一篇    下一篇

综述与进展

3-异硫氰酸酯氧化吲哚参与的不对称串联反应研究进展

谭芬a,b, 肖文精b, 曾国平a   

  1. a. 湖北第二师范学院 植物抗癌活性物质提纯与应用湖北省重点实验室 武汉 430205;
    b. 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079
  • 收稿日期:2016-11-15 修回日期:2016-12-21 出版日期:2017-04-25 发布日期:2017-01-04
  • 通讯作者: 谭芬 E-mail:tanfen@hue.edu.cn
  • 基金资助:

    国家自然科学基金(No.21602052)、湖北省教育厅科学技术研究(No.Q20163004)资助项目.

Recent Advances in 3-Isothiocyanato Oxindoles Engaged Asymmetric Cascade Reactions

Tan Fena,b, Xiao Wenjingb, Zeng Guopinga   

  1. a. Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Hubei University of Education, Wuhan 430205;
    b. Key Laboratory of Pesticide & Chemical Biology Ministry of Education and College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2016-11-15 Revised:2016-12-21 Online:2017-04-25 Published:2017-01-04
  • Contact: 10.6023/cjoc201611017 E-mail:tanfen@hue.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21602052) and the Scientific Research Project of Hubei Provincial Department of Education (No. Q20163004).

3-异硫氰酸酯氧化吲哚是一类高活性的新型反应试剂,已经被广泛地应用于串联反应中,并用于结构多样的手性螺环氧化吲哚骨架的构建. 简单综述了近六年来3-异硫氰酸酯氧化吲哚参与的几类串联环化反应的最新研究进展,主要介绍各反应的特点、活化模式及合成应用,并展望它的发展前景.

关键词: 3-异硫氰酸酯氧化吲哚, 螺环氧化吲哚, 不对称合成, 串联反应

3-Isothiocyanato oxindoles have been widely employed as a class of highly reactive and novel reagents in the enantioselective synthesis of diverse spirooxindoles. This review summarizes the recent advances of 3-isothiocyanato oxindoles mediated some types of cascade process in the past six years, including properties of reaction, activation models and synthetic applications. Furthermore, the prospects of this concept are also discussed.

Key words: 3-isothiocyanato oxindole, spirooxindole, asymmetric synthesis, cascade reaction