有机化学 ›› 2017, Vol. 37 ›› Issue (6): 1560-1564.DOI: 10.6023/cjoc201612044 上一篇    下一篇

研究简报

生物介质葡萄糖酸水溶液中5,5-(苯基亚甲基)双(2,2-二甲基二噁烷-4,6-二酮)衍生物的有效合成

林春花a, 袁建军a, 刘德永a, 张后富b, 许招会a   

  1. a. 江西师范大学化学化工学院 南昌 330022;
    b. 江西省中医药研究院 南昌 330026
  • 收稿日期:2016-12-14 修回日期:2017-01-24 出版日期:2017-06-25 发布日期:2017-02-15
  • 通讯作者: 许招会 E-mail:gotoxzh@163.com
  • 基金资助:

    国家科技攻关计划(No.2001BA323C)和江西省研究生创新基金(No.YC2015-B023)资助项目.

Efficient Synthesis of 5,5-(Phenylmethylene)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) Derivatives in Biobased Gluconic Acid Aqueous Solution

Lin Chunhuaa, Yuan Jianjuna, Liu Deyonga, Zhang Houfub, Xu Zhaohuia   

  1. a. Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022;
    b. Jiangxi Traditional Chinese Medecine Institute, Nanchang 330026
  • Received:2016-12-14 Revised:2017-01-24 Online:2017-06-25 Published:2017-02-15
  • Contact: 10.6023/cjoc201612044 E-mail:gotoxzh@163.com
  • Supported by:

    Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).

在生物介质葡萄糖酸水溶液中,以芳香醛和2,2-二甲基-1,3-二噁烷-4,6-二酮为原料,40℃合成了6种5,5-(苯基亚甲基)双(2,2-二甲基-1,3-二噁烷-4,6-二酮)衍生物.该反应具有收率高(81%~92%)、反应温和、操作简单及环境友好等优点.此外,葡萄糖酸溶液还可重复使用.

关键词: 葡萄糖酸水溶液, 芳香醛, 2, 2-二甲基-1, 3-二噁烷-4, 6-二酮, 5, 5-(苯基亚甲基)双(2, 2-二甲基-1, 3-二噁烷-4, 6-二酮)

Six kinds of 5,5-(phenylmethylene)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives were synthesized by the reaction of aromatic aldehydes and 2,2-dimethyl-1,3-dioxane-4,6-dione in biobased gluconic acid aqueous solution at 40 ℃. The reaction has the advantages of high yields (81%~92%), mild conditions, simple operation and environmental friendliness. Furthermore, GAAS can be reused for several times.

Key words: gluconic acid aqueous solution, aromatic aldehydes, 2,2-dimethyl-1,3-dioxane-4,6-dione, 5,5-(phenylmethylene)-bis(2,2-dimethyl-1,3-dioxane-4,6-dione)