有机化学 ›› 2017, Vol. 37 ›› Issue (8): 2159-2164.DOI: 10.6023/cjoc201612058 上一篇    下一篇

研究简报

高温水中2-甲基喹啉及2-甲基吡啶与芳醛的反应研究

肖尚友, 毕旌富, 穆小静, 周曌, 徐广   

  1. 重庆大学化学化工学院 重庆 400030
  • 收稿日期:2016-12-25 修回日期:2017-03-29 出版日期:2017-08-25 发布日期:2017-04-18
  • 通讯作者: 肖尚友 E-mail:xsy6508@163.com

Reaction of 2-Methylquinoline and 2-Methylpyridine with Aromatic Aldehydes in High Temperature Water

Xiao Shangyou, Bi Jingfu, Mu Xiaojing, Zhou Zhao, Xu Guang   

  1. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030
  • Received:2016-12-25 Revised:2017-03-29 Online:2017-08-25 Published:2017-04-18
  • Contact: 10.6023/cjoc201612058 E-mail:xsy6508@163.com

以高温水为溶剂,在不加催化剂的条件下合成了烷基氮杂芳烃衍生物.研究了反应温度、反应时间、反应物比例和水的用量对收率的影响.实验结果表明,通过C-H键的活化,2-甲基喹啉及2-甲基吡啶可以和各种芳香醛反应,合成2-甲基喹啉衍生物及2-甲基吡啶衍生物.该法无污染,且易于后处理.

关键词: 氮杂芳烃衍生物, 2-甲基喹啉, 2-甲基吡啶, 芳香醛, 高温水

Alkyl aza-arene derivatives were synthesized in high-temperature water without catalyst. The effects of temperature, reaction time, molar ratio of reactants and amount of water on the reaction were investigated. The results indicate that it is an efficient way to synthesize 2-methylquinoline derivatives and 2-methylpyridine derivatives from 2-methylquinoline and 2-methylpyridine with various aromatic aldehydes by C-H bond activation. This process is clean and easy to operate.

Key words: aza-arene derivatives, 2-methylquinoline, 2-methylpyridine, aldehyde, high-temperature water