有机化学 ›› 2017, Vol. 37 ›› Issue (9): 2175-2186.DOI: 10.6023/cjoc201705001 上一篇    下一篇

综述与进展

三或四取代单氟烯烃的高立体选择性合成研究进展

廖富民a, 余金生a, 周剑a,b   

  1. a 华东师范大学化学与分子工程学院 绿色化学与化工过程绿色化上海市重点实验室 上海 200062;
    b 中国科学院上海有机化学研究所 金属有机国家重点实验室 上海 200032
  • 收稿日期:2017-05-01 修回日期:2017-06-28 出版日期:2017-09-25 发布日期:2017-07-07
  • 通讯作者: 余金生, 周剑 E-mail:yujinsheng2011@163.com;jzhou@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21472049)资助项目.

Recent Advances in the Highly Stereoselective Synthesis of Tri-or Tetra-substituted Monofluoroalkenes

Liao Fumina, Yu Jinshenga, Zhou Jiana,b   

  1. a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2017-05-01 Revised:2017-06-28 Online:2017-09-25 Published:2017-07-07
  • Contact: 10.6023/cjoc201705001 E-mail:yujinsheng2011@163.com;jzhou@chem.ecnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472049).

单氟烯烃在新材料开发和新药研发等多个领域具有广泛的用途,其高立体选择性合成受到高度关注.本综述主要介绍了基于醛、酮、重氮化合物以及其他底物如炔烃、烯基金属物种以及烯烃的高立体选择性合成单氟烯烃的研究进展,并藉此讨论不同方法的一些优势和不足之处.

关键词: 单氟烯烃, 立体选择性合成, 醛和酮, 重氮化合物

Monofluoroalkenes have found applications in many areas of research, including the design and development new materials and drug. The highly stereoselective synthesis of this privileged structural motif has attracted great synthetic attention. This review summarizes recent progresses in highly stereoselective synthesis of monofluoroalkenes from aldehydes, ketones and diazo compounds, other substrates such as alkynes, alkenyl metallic species and alkenes are also included. The advantages and disadvantages of different methods are discussed.

Key words: monofluoroalkene, stereoselective synthesis, aldehyde and ketone, diazo compound