有机化学 ›› 2017, Vol. 37 ›› Issue (10): 2690-2696.DOI: 10.6023/cjoc201705004 上一篇    下一篇

研究论文

亚胺基吡咯酮类化合物的合成

赵宇澄, 肖强, 王保取, 林军, 严胜骄   

  1. 云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2017-05-02 修回日期:2017-06-16 出版日期:2017-10-25 发布日期:2017-06-23
  • 通讯作者: 林军, 严胜骄 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21362042,21662042,U1202221,21262042)、云南省自然科学基金(No.2017FA003)、云南省后备人才(2012HB001)、云南大学东陆学者,云南大学青年英才计划资助项目(No.XT412003).

Synthesis of Iminopyrrolone Compounds

Zhao Yucheng, Xiao Qiang, Wang Baoqu, Lin Jun, Yan Shengjiao   

  1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091
  • Received:2017-05-02 Revised:2017-06-16 Online:2017-10-25 Published:2017-06-23
  • Contact: 10.6023/cjoc201705004 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21362042,21662042,U1202221,21262042),the Natural Science Foundation of Yunnan Province (No.2017FA003),the Talent Found in Yunnan Province (No.2012HB001),the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University (No.XT412003).

建立了合成吡咯酮类化合物的新方法,该方法以1,1-烯二胺类化合物(1)和顺丁烯二酸酐(2)为原料,以三乙胺为碱在1,4-二氧六环溶剂中,加热回流,简洁、快速地合成了一系列亚胺类吡咯酮类化合物.产率68%~90%.该方法具有原料易得,操作简单,合成路线简洁等特点.

关键词: 亚氨基吡咯酮, 硝基烯胺, 合成

The method was constructed for synthesis of pyrrolone compounds, which was based on the reaction of 1,1-endiamine (1) with maleic anhydride (2) in 1,4-dioxane at reflux in alkali condition (Et3N). As a result, a series of iminopyrrolone compounds have been synthesized by this reaction. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.

Key words: iminopyrrolone, nitro-enamine, synthesis