有机化学 ›› 2018, Vol. 38 ›› Issue (4): 855-862.DOI: 10.6023/cjoc201709033 上一篇    下一篇

研究论文

微波促进下三组分反应构建3-取代吲哚衍生物

林伟a, 胡秀秀a, 王雅珍a, 宋帅a, 张梦烨b, 史达清b   

  1. a 江苏理工学院化学与环境工程学院 常州 213001;
    b 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2017-09-21 修回日期:2017-11-09 出版日期:2018-04-24 发布日期:2017-12-01
  • 通讯作者: 林伟, 史达清 E-mail:linwei@jsut.edu.cn;dqshi@suda.edu.cn
  • 基金资助:

    国家自然科学基金(No.21502074)、江苏省高校自然科学重大研究项目(15KJA150006)和江苏省大学生创新训练(No.201711463010Z)资助项目.

Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

Lin Weia, Hu Xiuxiua, Wang Yazhena, Song Shuaia, Zhang Mengyeb, Shi Daqingb   

  1. a School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001;
    b College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2017-09-21 Revised:2017-11-09 Online:2018-04-24 Published:2017-12-01
  • Contact: 10.6023/cjoc201709033 E-mail:linwei@jsut.edu.cn;dqshi@suda.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21502074), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006) and the College Students Practice Innovation Training Plan of Jiangsu Province (No. 201711463010Z).

吲哚化学的研究是杂环化学中最活跃的领域之一,特别是有关3-取代吲哚衍生物的合成.3-取代吲哚衍生物可以构建许多天然产物和相应具有生物活性化合物,其合成方法的研究格外令人关注.介绍了在微波辐射下,通过取代苯甲酰甲醛水合物、取代苯胺和4-羟基香豆素三组分,在三氟乙酸的催化下反应构建一系列官能团化的3-取代吲哚衍生物.该反应具有反应操作简单、原料廉价易得及原子经济性高等优点.

关键词: 吲哚, 合成, 三组分反应, 微波

The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.

Key words: indole, synthesis, three-component reaction, microwave