有机化学 ›› 2018, Vol. 38 ›› Issue (10): 2666-2672.DOI: 10.6023/cjoc201804030 上一篇    下一篇

研究论文

可见光催化的丙炔酸酯三氟乙基化反应合成香豆素类似物

方洁梅, 范为正, 冯柏年   

  1. 江南大学药学院 无锡 214122
  • 收稿日期:2018-04-16 修回日期:2018-05-22 出版日期:2018-10-25 发布日期:2018-06-06
  • 通讯作者: 冯柏年,E-mail:fengbainian@jiangnan.edu.cn E-mail:fengbainian@jiangnan.edu.cn
  • 基金资助:

    国家自然科学基金(No.21302066)资助项目.

Visible-Light Catalyzed Trifluoroethylation of Propiolates to Synthesize Coumarin Analogues

Fang Jiemei, Fan Weizheng, Feng Bainian   

  1. School of Pharmaceutical Science, Jiangnan University, Wuxi 214122
  • Received:2018-04-16 Revised:2018-05-22 Online:2018-10-25 Published:2018-06-06
  • Contact: 10.6023/cjoc201804030 E-mail:fengbainian@jiangnan.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302066).

可见光催化下以三氟碘乙烷为三氟乙基试剂,实现了丙炔酸酯的三氟乙基化,合成了三氟乙基取代的香豆素类似物.反应条件温和,后处理方便,环境友好,底物适用范围广泛.

关键词: 光催化, 丙炔酸酯, 三氟乙基化

A practical strategy has been described for the preparation of trifluoroethyl-coumarin derivatives using a visible-light-promoted trifluoroethylation reaction of propiolate with trifluoroethyl iodide. These reactions could be carried out at room temperature in good chemical yields with good functional group tolerance.

Key words: photocatalyst, propiolate, trifluoroethylation