有机化学 ›› 2019, Vol. 39 ›› Issue (3): 668-678.DOI: 10.6023/cjoc201807038 上一篇    下一篇

综述与进展

化学-酶多步串联反应及其在高附加值手性化合物高效、绿色合成中的应用

廖旭a, 蒋岩b, 赖石林a, 刘源岗b, 王士斌b, 熊兴泉a   

  1. a 华侨大学材料科学与工程学院 厦门 361021;
    b 华侨大学化工学院 厦门 361021
  • 收稿日期:2018-07-23 修回日期:2018-09-25 出版日期:2019-03-25 发布日期:2018-10-26
  • 通讯作者: 熊兴泉 E-mail:xxqluli@hqu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21004024)、福建省自然科学基金(No.2016J01063)、福建省“高校新世纪优秀人才支持计划”(No.2012FJ-NCET-ZR03)、福建省“高校杰出青年科研人才培育计划”(No.11FJPY02)及华侨大学研究生科研创新基金(No.ZQN-YX103)资助项目.

Chemoenzymatic Relay Reaction and Its Applications in Highly Efficient and Green Synthesis of High-Value Chiral Compounds

Liao Xua, Jiang Yanb, Lai Shilina, Liu Yuangangb, Wang Shibinb, Xiong Xingquana   

  1. a College of Materials Science and Engineering, Huaqiao University, Xiamen 361021;
    b College of Chemical Engineering, Huaqiao University, Xiamen 361021
  • Received:2018-07-23 Revised:2018-09-25 Online:2019-03-25 Published:2018-10-26
  • Contact: 10.6023/cjoc201807038 E-mail:xxqluli@hqu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21004024), the Natural Science Foundation of Fujian Province (No. 2016J01063), the Program for New Century Excellent Talents in Fujian Province (No. 2012FJ-NCET-ZR03), the University Distinguished Young Research Talent Training Program of Fujian Province (No. 11FJPY02) and the Subsidized Project for Postgraduates' Innovative Fund in Scientific Research of Huaqiao University (No. ZQN-YX103).

与化学催化或酶催化合成相比,化学-酶相结合的多步串联反应是一种更简单、高效、经济的方法,兼具酶催化剂的高效、高选择性等优点,且合成原料价廉易得,合成工艺简捷高效,生产环境绿色友好,所得产品光学纯度高,使其在高附加值手性化合物的开发和合成方面得到了广泛的应用.近年来,化学家们通过改变催化剂和设计更为合理的反应方式,致力于将化学-酶催化反应条件变得更为容易,从而将其应用于更多反应领域.综述了近年来国内外化学-酶多步串联反应,如酶与金属催化、酶与有机催化、酶与新型反应技术等相结合多步串联合成手性醇类、环氧类、杂环类以及其他手性化合物的研究进展,并对该领域的发展趋势进行了展望.

关键词: 化学-酶, 串联反应, 高附加值手性化合物, 酶-金属催化, 酶-有机催化

Compared with traditional chemical catalysis or enzymatic synthesis, chemoenzymatic relay reaction is a simpler, more efficient and economical method. It not only has the advantages of high efficiency and selectivity of enzyme catalysis, but also has the advantages of low price of synthetic raw materials, simple and high efficiency of synthetic process, green and friendly production environment, and excellent optical purity of the obtained product. Thus, chemoenzymatic relay synthesis methods have been widely used in the synthesis of high-value chiral compounds. In recent years, chemists have been committed to making chemoenzymatic catalytic conditions easier by changing catalysts and designing more reasonable ways, which could be used in more fields. In this review, the recent progress in the synthesis of chiral alcohols, epoxides, heterocyclics and other chiral compounds by using chemoenzymatic relay synthesis, such as enzyme and metal catalysis, enzyme and organic catalysis, enzyme and new reaction techniques, is reviewed, and the development trends of this field are also prospected.

Key words: chemoenzymatic, relay reaction, high-value chiral compound, enzyme-metal catalysis, enzyme-organic catalysis